72-785
Tocris Bioscience™ a1A-AR Degrader 9c
Manufacturer: Tocris Bioscience™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 72-785-Each-of-1 | In Stock | ₹ 38,715.90 |
72-785 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 38,715.90
GST (18%): ₹ 6,968.862
Total Price: ₹ 45,684.762
Chemical Name or Material
2-(2-(2-(2-(4-(4-(4-Amino-6,7-dimethoxyquinazolin-2-yl)piperazine-1-carbonyl)-1 H-1,2,3-triazol-1-yl)ethoxy)ethoxy)ethoxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)acetamide
Target
Active Degraders
Purity
0.98
Quantity
5 mg
Molecular Formula
C38H43N11O11
Related Products
Description
- α1A-AR Degrader 9c is a selective α1A-adrenergic receptor Degrader (PROTAC®; DC50 = 2.86 μM, 94% α1A-adrenoceptor degradation at 10 μM for 12 h)
- It comprises the α-adrenoceptor antagonist Prazosin (Cat
- No
- 0623), joined by a linker to a cereblon ligand Pomalidomide (Cat
- No
- 6302)
- α1A-AR Degrader 9c selectively downregulates α1A-adrenoceptor levels, but not α1B-AR and α1D-AR in HEK293 cells
- α1A-AR Degrader 9c shows concentration-dependent antiproliferative activity in PC-3 prostate cancer cells (IC50 = 6.12 μM) in vitro , and PC-3 tumor xenografts in vivo
- PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license .
SAFETY INFORMATION
- Recommended Storage : Store at -20°C
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Chemical Name or Material: 2-(2-(2-(2-(4-(4-(4-Amino-6,7-dimethoxyquinazolin-2-yl)piperazine-1-carbonyl)-1 H-1,2,3-triazol-1-yl)ethoxy)ethoxy)ethoxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)acetamide
Target: Active Degraders
Purity: 0.98
Quantity: 5 mg
Molecular Formula: C38H43N11O11
Chemical Name or Material:
2-(2-(2-(2-(4-(4-(4-Amino-6,7-dimethoxyquinazolin-2-yl)piperazine-1-carbonyl)-1 H-1,2,3-triazol-1-yl)ethoxy)ethoxy)ethoxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)acetamide
Target:
Active Degraders
Purity:
0.98
Quantity:
5 mg
Molecular Formula:
C38H43N11O11
Chemical Name or Material: 5-Amino-2-methyl-N-[(1 R)-1-(1-naphthalenyl)ethyl]benzamide
Target: Papain-like Protease Inhibitors
Purity: 0.98
Quantity: 25 mg
Molecular Formula: C20H20N2O
Chemical Name or Material:
5-Amino-2-methyl-N-[(1 R)-1-(1-naphthalenyl)ethyl]benzamide
Target:
Papain-like Protease Inhibitors
Purity:
0.98
Quantity:
25 mg
Molecular Formula:
C20H20N2O
Chemical Name or Material: B-[(1 R)-3-Methyl-1-[[(2 S)-1-oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)amino]propyl]amino]butyl]boronic acid
Target: Proteasome Inhibitors
Purity: 0.98
Quantity: 25 mg
Molecular Formula: C19H25BN4O4
Chemical Name or Material:
B-[(1 R)-3-Methyl-1-[[(2 S)-1-oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)amino]propyl]amino]butyl]boronic acid
Target:
Proteasome Inhibitors
Purity:
0.98
Quantity:
25 mg
Molecular Formula:
C19H25BN4O4
Chemical Name or Material: B-[(1 R)-3-Methyl-1-[[(2 S)-1-oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)amino]propyl]amino]butyl]boronic acid
Target: Proteasome Inhibitors
Purity: 0.98
Quantity: 5 mg
Molecular Formula: C19H25BN4O4
Chemical Name or Material:
B-[(1 R)-3-Methyl-1-[[(2 S)-1-oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)amino]propyl]amino]butyl]boronic acid
Target:
Proteasome Inhibitors
Purity:
0.98
Quantity:
5 mg
Molecular Formula:
C19H25BN4O4