75-305
Tocris Bioscience™ dTAG-47
Manufacturer: Tocris Bioscience™
CAS Number: 2265886-81-3
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 75-305-Each-of-1 | In Stock | ₹ 53,177.50 |
75-305 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 53,177.50
GST (18%): ₹ 9,571.95
Total Price: ₹ 62,749.45
Chemical Name or Material
(1 R)-3-(3,4-Dimethoxyphenyl)-1-(2-(2-((8-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)octyl)amino)-2-oxoethoxy)phenyl)propyl (2 S)-1-(-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate
Quantity
5 mg
Molecular Formula
C59H73N5O14
CAS
2265886-81-3
Target
Active Degraders
Purity
0.97
Related Products
Description
- dTAG-47 is a degrader targeting mutant FKBP12F36V fusion proteins
- Comprises a ligand selective for F36V single-point mutated FKBP12, a linker and a cereblon-binding ligand
- Application of dTAG-47 induces rapid, reversible and selective degradation of FKBP12F36V fusion proteins in vitro and in vivo
- dTAG is generalizable to a range of fusion proteins; useful as an alternative to genetic methods for target validation
- See also dTAG-13 and dTAG-7
- Negative control (Cat
- No
- 7531) also available
- FKBP12F36V can be expressed as a fusion with a target protein of interest using genome engineering techniques, via transgene expression or CRISPR-mediated locus-specific knock-in
- Custom knock-in cell lines for the dTAG and aTAG platforms are available from our sister brand R&D Systems
- Email TPD@bio-techne.com to enquire
- Plasmid vectors for the lentiviral expression and CRISPR-mediated knock-in of FKBP12F36V are available from Addgene.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C
Compare Similar Items
Show Difference
Chemical Name or Material: (1 R)-3-(3,4-Dimethoxyphenyl)-1-(2-(2-((8-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)octyl)amino)-2-oxoethoxy)phenyl)propyl (2 S)-1-(-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate
Quantity: 5 mg
Molecular Formula: C59H73N5O14
CAS: 2265886-81-3
Target: Active Degraders
Purity: 0.97
Chemical Name or Material:
(1 R)-3-(3,4-Dimethoxyphenyl)-1-(2-(2-((8-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)octyl)amino)-2-oxoethoxy)phenyl)propyl (2 S)-1-(-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate
Quantity:
5 mg
Molecular Formula:
C59H73N5O14
CAS:
2265886-81-3
Target:
Active Degraders
Purity:
0.97
Chemical Name or Material: __
Quantity: 100 μg
Molecular Formula: __
CAS: __
Target: __
Purity: __
Chemical Name or Material:
__
Quantity:
100 μg
Molecular Formula:
__
CAS:
__
Target:
__
Purity:
__
Chemical Name or Material: (1 R)-3-(3,4-Dimethoxyphenyl)-1-(2-(2-((8-((1,3-dioxo-2-(2-oxopiperidin-3-yl)isoindolin-5-yl)amino)octyl)amino)-2-oxoethoxy)phenyl)propyl (2 S)-1-(-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate
Quantity: 5 mg
Molecular Formula: C59H75N5O13
CAS: __
Target: Active Degrader Negative Controls
Purity: 0.97
Chemical Name or Material:
(1 R)-3-(3,4-Dimethoxyphenyl)-1-(2-(2-((8-((1,3-dioxo-2-(2-oxopiperidin-3-yl)isoindolin-5-yl)amino)octyl)amino)-2-oxoethoxy)phenyl)propyl (2 S)-1-(-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate
Quantity:
5 mg
Molecular Formula:
C59H75N5O13
CAS:
__
Target:
Active Degrader Negative Controls
Purity:
0.97
Chemical Name or Material: 3-(Difluoromethyl)-N-(6-((5 R,6 R)-6-hydroxy-6,7,8,9-tetrahydro-5 H-imidazo[1,5-a]azepin-5-yl)-[1,10-biphenyl]-3-yl)-1-isopropyl-1 H-pyrazole-5-carboxamide
Quantity: 2 mg
Molecular Formula: C28H29F2N5O2
CAS: __
Target: Ubiquitin Ligase (E3) Inhibitors
Purity: 0.98
Chemical Name or Material:
3-(Difluoromethyl)-N-(6-((5 R,6 R)-6-hydroxy-6,7,8,9-tetrahydro-5 H-imidazo[1,5-a]azepin-5-yl)-[1,10-biphenyl]-3-yl)-1-isopropyl-1 H-pyrazole-5-carboxamide
Quantity:
2 mg
Molecular Formula:
C28H29F2N5O2
CAS:
__
Target:
Ubiquitin Ligase (E3) Inhibitors
Purity:
0.98