RDC2579
R&D Systems™ Cynomolgus Monkey VSIG4 (XP_005593850) VersaClone cDNA
Manufacturer: R&D Systems™
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | RDC2579-Each-of-1 | In Stock | ₹ 25,796.34 |
RDC2579 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 25,796.34
GST (18%): ₹ 4,643.341
Total Price: ₹ 30,439.681
Gene
VSIG4
Concentration
10 μg at 0.2 μg/μL
Insert Type
1228 bp
Gene Alias
CRIg, Ig superfamily protein, Protein Z39Ig, V-set and immunoglobulin domain containing 4, V-set and immunoglobulin domain-containing protein 4, Z39IG, Z39IGcomplement receptor of the immunoglobulin superfamily
Species
Cynomolgus Monkey
Accession Number
XP_005593850
Formulation
cDNA is provided in 10 mM Tris-Cl, pH 8.5
Gene ID (Entrez)
11326
Content And Storage
Store the unopened product at -20°C to -70°C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Quantity
10 μg
Related Products
Description
- VSIG4 (V-set and immunoglobulin domain containing 4), also known as CRIg and Z39IG, is a 45 kDa, type I transmembrane protein of the B7 family within the Ig superfamily that is expressed only in tissue-resident macrophages
- The gene is located on the X chromosome
- The human VSIG4 cDNA encodes 399 amino acids (aa) including a 19 aa signal sequence, a 264 aa extracellular domain (ECD) containing a V-type and a C2-type Ig domain, a 21 aa transmembrane domain and a 95 aa cytoplasmic domain
- The human VSIG4 ECD shares 84% aa identity with canine VSIG4
- Within the IgV domain, it shares 90%, 80% and 78% aa identity with bovine, mouse and rat VSIG4, respectively; these animals lack the C2-type domain
- Splice isoforms of 321, 305, 272, 201 and 199 aa lack all or part of the cytoplasmic domain, the C2-type Ig domain and/or the transmembrane domain
- VSIG4 is specifically expressed on macrophages in the thymic medulla, peritoneum, alveoli, synovia, adipose and heart, liver Kupffer cells, placental Hofbauer cells, and atherosclerotic foam cells
- It is absent on infiltrating macrophages
- VSIG4 is a complement receptor that binds C3b and iC3b fragments, internalizes them to recycling endosomes, and is recycled to the cell surface
- It contributes significantly to innate immunity by binding and phagocytosis of complement-opsonized invading pathogens
- Binding of either native or recombinant soluble VSIG4 to C3b inhibits complement amplification through the alternative, but not classical, pathway
- VSIG4 is also a negative regulator of mouse and human T cell activation
- Although VSIG4 engagement may activate NF-kappa-B and thus be pro-inflammatory in some cases, many of its activities are important in resolving, rather than initiating, inflammation
- The VSIG4 insert is sequence verified and the entire plasmid DNA and insert translated sequences are provided
- For reasearch use only
- Not for use in humans.
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Gene: VSIG4
Concentration: 10 μg at 0.2 μg/μL
Insert Type: 1228 bp
Gene Alias: CRIg, Ig superfamily protein, Protein Z39Ig, V-set and immunoglobulin domain containing 4, V-set and immunoglobulin domain-containing protein 4, Z39IG, Z39IGcomplement receptor of the immunoglobulin superfamily
Species: Cynomolgus Monkey
Accession Number: XP_005593850
Formulation: cDNA is provided in 10 mM Tris-Cl, pH 8.5
Gene ID (Entrez): 11326
Content And Storage: Store the unopened product at -20°C to -70°C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Quantity: 10 μg
Gene:
VSIG4
Concentration:
10 μg at 0.2 μg/μL
Insert Type:
1228 bp
Gene Alias:
CRIg, Ig superfamily protein, Protein Z39Ig, V-set and immunoglobulin domain containing 4, V-set and immunoglobulin domain-containing protein 4, Z39IG, Z39IGcomplement receptor of the immunoglobulin superfamily
Species:
Cynomolgus Monkey
Accession Number:
XP_005593850
Formulation:
cDNA is provided in 10 mM Tris-Cl, pH 8.5
Gene ID (Entrez):
11326
Content And Storage:
Store the unopened product at -20°C to -70°C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Quantity:
10 μg
Gene: mClec4a2
Concentration: 10 μg at 0.2 μg/μL
Insert Type: 730 bp
Gene Alias: __
Species: Mouse
Accession Number: NP_036129
Formulation: cDNA is provided in 10 mM Tris-Cl, pH 8.5
Gene ID (Entrez): 50856
Content And Storage: Store the unopened product at -20°C to -70°C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Quantity: 10 μg
Gene:
mClec4a2
Concentration:
10 μg at 0.2 μg/μL
Insert Type:
730 bp
Gene Alias:
__
Species:
Mouse
Accession Number:
NP_036129
Formulation:
cDNA is provided in 10 mM Tris-Cl, pH 8.5
Gene ID (Entrez):
50856
Content And Storage:
Store the unopened product at -20°C to -70°C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Quantity:
10 μg
Gene: B3GALNT1
Concentration: 10 μg at 0.2 μg/μL
Insert Type: 1009 bp
Gene Alias: b3Gal-T3, B3GALT3, Beta-1,3-galactosyltransferase 3, Beta-1,3-GalNAc-T1, Beta-1,3-GalTase 3, beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group), Beta3GalT3, Beta3Gal-T3, beta-3-Gx-T3, brainiac1, EC 2.4.1.79, Galactosylgalactosylglucosylceramide beta-D-acetyl-galactosaminyltransferase, Gb4Cer, GLCT3, Globoside Synthase, globotriaosylceramide 3-beta-N-acetylgalactosaminyltransferase, P, P antigen synthase, P blood group globoside, polypeptide 3 (Globosideblood group), UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1, UDP-GalNAc:betaGlcNAc beta 1,3-galactosaminyltransferase, polypeptide 1(Globoside blood group), UDP-GalNAc:betaGlcNAc beta-1,3-galactosaminyltransferase, polypeptide 1(Globoside blood group), UDP-N-acetylgalactosamine:globotriaosylceramidebeta-1,3-N-acetylgalactosaminyltransferase
Species: Human
Accession Number: NP_003772
Formulation: cDNA is provided in 10 mM Tris-Cl, pH 8.5
Gene ID (Entrez): 8706
Content And Storage: Store the unopened product at -20°C to -70°C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Quantity: 10 μg
Gene:
B3GALNT1
Concentration:
10 μg at 0.2 μg/μL
Insert Type:
1009 bp
Gene Alias:
b3Gal-T3, B3GALT3, Beta-1,3-galactosyltransferase 3, Beta-1,3-GalNAc-T1, Beta-1,3-GalTase 3, beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group), Beta3GalT3, Beta3Gal-T3, beta-3-Gx-T3, brainiac1, EC 2.4.1.79, Galactosylgalactosylglucosylceramide beta-D-acetyl-galactosaminyltransferase, Gb4Cer, GLCT3, Globoside Synthase, globotriaosylceramide 3-beta-N-acetylgalactosaminyltransferase, P, P antigen synthase, P blood group globoside, polypeptide 3 (Globosideblood group), UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1, UDP-GalNAc:betaGlcNAc beta 1,3-galactosaminyltransferase, polypeptide 1(Globoside blood group), UDP-GalNAc:betaGlcNAc beta-1,3-galactosaminyltransferase, polypeptide 1(Globoside blood group), UDP-N-acetylgalactosamine:globotriaosylceramidebeta-1,3-N-acetylgalactosaminyltransferase
Species:
Human
Accession Number:
NP_003772
Formulation:
cDNA is provided in 10 mM Tris-Cl, pH 8.5
Gene ID (Entrez):
8706
Content And Storage:
Store the unopened product at -20°C to -70°C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Quantity:
10 μg
Gene: hKLRC3
Concentration: 10 μg at 0.2 μg/μL
Insert Type: 736 bp
Gene Alias: KLRC3, NKG2E, NKG2-E
Species: Human
Accession Number: NP_002252
Formulation: cDNA is provided in 10 mM Tris-Cl, pH 8.5
Gene ID (Entrez): 3823
Content And Storage: Store the unopened product at -20°C to -70°C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Quantity: 10 μg
Gene:
hKLRC3
Concentration:
10 μg at 0.2 μg/μL
Insert Type:
736 bp
Gene Alias:
KLRC3, NKG2E, NKG2-E
Species:
Human
Accession Number:
NP_002252
Formulation:
cDNA is provided in 10 mM Tris-Cl, pH 8.5
Gene ID (Entrez):
3823
Content And Storage:
Store the unopened product at -20°C to -70°C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Quantity:
10 μg