MilliporeSigma™ Calbiochem™ InSolution™ CFTR Inhibitor II, GlyH-101

Description

• A cell-permeable glycinyl hydrazone compound that acts as a potent, selective and reversible open-channel blocker of CFTR with intermediate speed (<1 min; 95% inhibition at 50μM; K i = 4.3μM in CFTR-expressing FRT cells for apical membrane Cl - current) and exhibits desirable aqueous solubility
• Shown to produce inwardly rectifying CFTR Cl - currents with reduced mean channel open time and suggested to directly interact with the channel pore at the extracellular side of the membrane
• Displays minimal effects on P-glycoprotein and non-CFTR-mediated Cl - currents, and is effective in nasal and intestinal epithelia in vivo .