Thermo Scientific™ CaptureSelect™ TSH Affinity Matrix

Description

• CaptureSelect TSH Affinity Matrix was specifically designed for the purification of thyroid-stimulating hormone (TSH) from recombinant sources
• Some features of CaptureSelect TSH Affinity Matrix include: Highly selective for thyroid-stimulating hormone with no affinity for the other gonadotropins (FSH, LH, and HCG) Enables efficient purification of recombinant TSH with high yields and retained activity Offers excellent scalability Non–animal-derived The high selectivity and yields obtained using CaptureSelect TSH Affinity Matrix enable a robust and efficient purification process with excellent purity obtained in one step
• Free of animal components CaptureSelect products contain affinity ligands based on recombinant single-domain antibody fragments (VHH) created by a proprietary technology
• The VHH affinity ligand is a 12 to 15 kDa fragment comprising the three complementarity-determining regions (CDRs) that form the antigen-binding domain, efficiently produced in the yeast Saccharomyces cerevisiae by a production process free of any animal components (Animal Origin-Free)
• Main characteristics: Matrix: agarose bead Average particle size: 65 μm Ligand: CaptureSelect TSH affinity ligand Ligand coupling method: epoxide Binding capacity: >5 mg/mL of resin Elution conditions: 0.1 M citrate buffer, pH 3.0 Flow characteristics: 50–200 cm/h (up to 2 bar) Formulation buffer: 20% (v/v) ethanol