31-770-125MG
MilliporeSigma™ Calbiochem™ Dkk Inhibitor II, IIIC3a
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 31-770-125MG-Each-of-1 | In Stock | ₹ 19,523.04 |
31-770-125MG - Each of 1
In Stock
Quantity
1
Base Price: ₹ 19,523.04
GST (18%): ₹ 3,514.147
Total Price: ₹ 23,037.187
Color
Black
Target Proteins
LRP5/6
Solubility
DMSO or H2O
Form
Powder
Description
90% by HPLC
Molecular Formula
C16H16I2N2O5
Content And Storage
Hygroscopic, Protect from light
Quantity
25 mg
Related Products
Description
- An enhanced in solution stable gallocyanine analog that directly and reversibly targets human LRP5/6 (low density lipoprotein-related protein 5/6), and disrupts its interaction with Dkk (Dickkopf) in a competitive manner
- Shown to potently reverse DKK1/2/4-mediated inhibition of WNT3A-stimulated reporter gene activity (IC 50 ∽ 10 - 30μM in in NIH 3T3 cells) with no effects on sFRP4-mediated inhibition of Wnt signaling
- Blocks Dkk-2 - alkaline phosphatase binding to cells expressing LRP5 (IC 50 = 1μM in LRP5 transfected NIH 3T3 cells)
- Reduces blood glucose levels, improves glucose tolerance, and increases insulin sensitivity in type 2 diabetic mice (1.5mg/kg, i.p
- daily), mainly via its antagonistic action on DKK2
- These effects are not observed in DKK2 -/- mice.
Compare Similar Items
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Color: Black
Target Proteins: LRP5/6
Solubility: DMSO or H2O
Form: Powder
Description: 90% by HPLC
Molecular Formula: C16H16I2N2O5
Content And Storage: Hygroscopic, Protect from light
Quantity: 25 mg
Color:
Black
Target Proteins:
LRP5/6
Solubility:
DMSO or H2O
Form:
Powder
Description:
90% by HPLC
Molecular Formula:
C16H16I2N2O5
Content And Storage:
Hygroscopic, Protect from light
Quantity:
25 mg
Color: Clear colorless
Target Proteins: __
Solubility: __
Form: __
Description: __
Molecular Formula: __
Content And Storage: __
Quantity: 1 L
Color:
Clear colorless
Target Proteins:
__
Solubility:
__
Form:
__
Description:
__
Molecular Formula:
__
Content And Storage:
__
Quantity:
1 L
Color: __
Target Proteins: __
Solubility: __
Form: Powder
Description: __
Molecular Formula: __
Content And Storage: Storage conditions: 2-8° CShipping conditions: AmbientShelf life: 36 months from date of manufacture
Quantity: 10 x 1 L
Color:
__
Target Proteins:
__
Solubility:
__
Form:
Powder
Description:
__
Molecular Formula:
__
Content And Storage:
Storage conditions: 2-8° CShipping conditions: AmbientShelf life: 36 months from date of manufacture
Quantity:
10 x 1 L
Color: __
Target Proteins: __
Solubility: __
Form: Powder
Description: __
Molecular Formula: __
Content And Storage: Storage conditions: 2-8° CShipping conditions: AmbientShelf life: 36 months from date of manufacture
Quantity: 10 L
Color:
__
Target Proteins:
__
Solubility:
__
Form:
Powder
Description:
__
Molecular Formula:
__
Content And Storage:
Storage conditions: 2-8° CShipping conditions: AmbientShelf life: 36 months from date of manufacture
Quantity:
10 L