Description

• Cyclic heptapeptide toxin isolated from the freshwater cyanobacteria Microcystis aeruginosa
• Potent inhibitor of protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A)
• Unlike Okadaic Acid (Cat
• No
• 495604), microcystin-LR is effective on both PP1 (IC 50 = 1.7 nM) and PP2A (IC 50 = 40 pM)
• Reacts with phosphatase in a two-step mechanism involving rapid binding and inactivation of the catalytic subunit followed by slower covalent interactions
• Has no effect on protein kinases, making it useful for reducing the effect of contaminating phosphatase activities in protein kinase assays
• A 2.5mm (250μg/100μl) solution of Microcystin-LR, Microcystis aeruginosa (Cat
• No
• 475821) in DMSO is also available.