50-065-50001

MilliporeSigma™ Calbiochem™ Rad6 Inhibitor, TZ9

Manufacturer: MilliporeSigma™

Select a Size

Pack Size SKU Availability Price
Each of 1 50-065-50001-Each-of-1 In Stock ₹ 19,451.21

50-065-50001 - Each of 1

₹ 19,451.21

In Stock

Quantity

1

Base Price: ₹ 19,451.21

GST (18%): ₹ 3,501.218

Total Price: ₹ 22,952.428

Color

Pale Yellow

Target Proteins

Rad6B/HHR6B

Solubility

DMSO

Quantity

10 mg

Description

99% by HPLC

Molecular Formula

C17H14N6O4

Form

Solid

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Description

  • A cell-permeable triazine compound that directly targets human E2 Ubiquitin-conjugating enzyme Rad6B/HHR6B catalytic site via noncovalent interactions and effectively inhibits Rad6B-Ub thioester bond formation as well as subsequent substrate ubiquitination without affecting UbcH5B/UBE2D2-catalyzed BCA2 ubiquitination
  • Shown to inhibit the proliferation of high Rad6B-expressing MDA-MB-231 (IC 50 = 6μM in 72 h), but not the low Rad6B-expressing, non-transformed MCF10A, via G2/M arrest and apoptosis induction
  • Two known cellular Rad6 substrates, β-catenin and PCNA, are reported to be downregulated following 24 h inhibitor treatment in MDA-MB-231 cultures (0.5 to 5μM).

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50-065-50001

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Color:
Pale Yellow

Target Proteins:
Rad6B/HHR6B

Solubility:
DMSO

Quantity:
10 mg

Description:
99% by HPLC

Molecular Formula:
C17H14N6O4

Form:
Solid

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