61-485-210MG

MilliporeSigma™ Calbiochem™ Topoisomerase IIα Inhibitor, TSC24

Manufacturer: MilliporeSigma™

Select a Size

Pack Size SKU Availability Price
Each of 1 61-485-210MG-Each-of-1 In Stock ₹ 16,024.53

61-485-210MG - Each of 1

₹ 16,024.53

In Stock

Quantity

1

Base Price: ₹ 16,024.53

GST (18%): ₹ 2,884.415

Total Price: ₹ 18,908.945

Color

Yellow

Molecular Formula

C13H14N4S

Solubility

DMSO

Quantity

10 mg

Description

95% by HPLC

Formula Weight

258.34g/mol

Form

Powder

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Description

  • A cell-permeable, TSC (thiosemicarbazone) derivative that acts as a selective and ATP competitive Topoisomerase IIα inhibitor and Fe chelator
  • Independent of its Fe chelating ability, this compound is shown to block Topo II&alpha-catalyzed ATP hydrolysis by competing with ATP for binding to the ATPase domain of Topo IIα (K d = 18μM)
  • It also displays M phase cell-cycle arrest at 1μM in nocodazole-treated HT-29 cells
  • This compound demonstrates anti-proliferative activity, without distinct or obvious selectivity, towards HeLa, HL-60, SGC7901, and HT-29 cultures (IC 50 = 90 nM, 50 nM, 30 nM, and 20 nM, respectively), and a broader panel of tumor cell lines with IC 50 values in the nanomolar range.

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MilliporeSigma™

61-485-210MG

--


Color:
Yellow

Molecular Formula:
C13H14N4S

Solubility:
DMSO

Quantity:
10 mg

Description:
95% by HPLC

Formula Weight:
258.34g/mol

Form:
Powder

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MilliporeSigma™

61-485-310MG

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Color:
White

Molecular Formula:
C24H25NO5

Solubility:
DMSO

Quantity:
10 mg

Description:
99% by HPLC

Formula Weight:
407.46g/mol

Form:
Solid

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Invitrogen

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Molecular Formula:
__

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Formula Weight:
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Fischer Scientific

61-531-0

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Color:
__

Molecular Formula:
C30H38N8O2

Solubility:
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Quantity:
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Description:
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Formula Weight:
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Form:
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