MilliporeSigma™ Calbiochem™ 3,3'-Diamino-4'-methoxyflavone, DD1

Description

• A cell-permeable flavone derivative that arrests the proliferation of acute myeloid leukemia cells (NB4, U937, HL-60, OCI AML3), in a dose and time-dependent manner (optimum at ∽20μM and 96 h) and blocks the colony formation in samples from acute myeloid leukemia patients, without affecting normal blood cells
• Shown to reduce mitochondrial membrane potential and Bad phosphorylation (at Ser136), induce Bax and caspase 3, 8, and 9 activation in U937 cells
• Does not affect the phosphorylation of Akt1, but significantly reduces the expression and phosphorylation of p70S6 kinase in U937 cells
• Reported to inhibit the chymotrypsin-like activity of proteasome (IC 50 = 2.0μM) and this effect is synergistic with bortezomib (Cat
• No
• 504314).