MilliporeSigma™ Calbiochem™ Gap Junction Enhancer, PQ7

Description

• A cell-permeable quinoline derived compound with low toxicity that enhances gap junctional activity by about 16-fold (at ∽500nM) in T47D breast cancer cells and thereby potentiates the effect of chemotherapeutic agents
• Blocks T47D cell colony formation (IC 50 = 100nM) and reduce the growth of T47D xenograft tumors by 100% in Nu/Nu mice
• Increases caspase-3, - 8, and -9 expression by 1.6, 2.8, and 3.8-fold, respectively to induce apoptotic cell death
• Can work synergistically with cisplatin to reduce or totally eliminate tumor growth
• Increases the expression of connexins 26, 32, and 43 to allow more efficient trafficking of cisplatin.