MilliporeSigma™ Calbiochem™ c-Raf Inhibitor

Description

• A cell-permeable pyrazoloimidazole phenyl urea derivative that acts as a selective type II inhibitor of c-Raf
• It shows an IC 50 value of 50nM in an enzymatic assay, and comparable anti-proliferative activities to sorafenib against A375P (GI 50 = 2.68μM) and WM3629 (GI 50 = 0.86μM) human melanoma cell lines
• When screening against a panel of 30 different kinases at a concentration of 10μM, it exerts an inhibitory activity of 96% on c-Raf, but below 50% for most of the other kinases.