MilliporeSigma™ Calbiochem™ PI3Kδ Inhibitor, SW30

Description

• A cell permeable, ATP-competitive and selective tolyl quinazolinone inhibitor of PI 3-Kδ (IC 50 = 7 nM, 1300 nM, 85000 nM, and 740nM for PI 3-Kδ PI 3-Kγ PI 3-Kα and PI 3-Kβ, respectively) in an enzymatic assay with an EC 50 = 16nM for PI 3-Kδ and 2.7μM for PI 3-Kγ in a cell based assay
• It elicits an inflammatory marker suppression effect in co-cultures of HUVEC and PBMCs under superantigen stimulated conditions
• This compound, at concentrations between 370nM and 10μM, leads to a dose-dependent decrease in E-selectin expression
• Furthermore, it is not cytotoxic to HUVEC cells.