MilliporeSigma™ Calbiochem™ PI 3-K Inhibitor XVIII

Description

• An N-myristoylated cell-permeable PI 3-K p110β-derived Gβγ-binding peptide (aa 514-537 in p110β C2-helical linker region) that prevents Gβγ-, but not RTK-, mediated p100β activation both in cell-free assays (1μM) and in cultures (30μM in p110β/p85/Akt/Gβγ-transfected HEK 293E cells) without affecting basal p100β activity, p110β-Rab5 interaction, nor Gβγ-dependent activation of adenylyl cyclase or p101-p110γ dimer
• The ATP-competitive p110β inhibitior TGX-221 (Cat
• No
• 528113) can be used in conjunction for studying Gβγ dependency of p110β-mediated cellular functions
• Please note that the molecular weight for this compound is batch-specific due to variable water content
• Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight
• The molecular weight provided represents the baseline molecular weight without water.