50-437-90001

MilliporeSigma™ Calbiochem™ HIF Inhibitor VII

Manufacturer: MilliporeSigma™

Select a Size

Pack Size SKU Availability Price
Each of 1 50-437-90001-Each-of-1 In Stock ₹ 24,680.64

50-437-90001 - Each of 1

₹ 24,680.64

In Stock

Quantity

1

Base Price: ₹ 24,680.64

GST (18%): ₹ 4,442.515

Total Price: ₹ 29,123.155

Color

Yellow

Target Proteins

HIF-2α

Solubility

DMSO

Form

Powder

Description

99% by HPLC

Molecular Formula

C12H6ClFN4O3

Content And Storage

Protect from light

Quantity

10 mg

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Description

  • A cell-permeable benzoxadiazolamine that prevents HIF-2α-HIF-β/ARNT heterodimeration by perturbing HIF-2α Per-ARNT-Sim/PAS-B domain surface β-sheet conformation via a 1:1 stoichiometric binding ( K D = 81nM), while exhibiting no affinity toward HIF-1αPAS-B domain
  • Shown to be metabolically stable and non-cytotoxic in cultures and selectively inhibit hypoxia-induced HIF-2α DNA binding and HIF-2α-dependent EPO mRNA upregulation (1 to10μM for 6 to 12 h), but not HIF-1α DNA binding or HIF-1α-dependent PGK1 mRNA upregulation, in Hep3B cells
  • Unlike HIF Inhibitors I-VI, this compound does not affect the cellular protein or mRNA levels of HIF-1α & HIF-2α.

Compare Similar Items

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Img

MilliporeSigma™

50-437-90001

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Color:
Yellow

Target Proteins:
HIF-2α

Solubility:
DMSO

Form:
Powder

Description:
99% by HPLC

Molecular Formula:
C12H6ClFN4O3

Content And Storage:
Protect from light

Quantity:
10 mg

Img

Matrix Scientific

50-437-918

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Color:
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Target Proteins:
__

Solubility:
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Form:
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Description:
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Molecular Formula:
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Content And Storage:
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Matrix Scientific

50-437-919

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Color:
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Solubility:
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Form:
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Description:
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New England Biolabs, Inc.

50-438-1

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Color:
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Target Proteins:
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Solubility:
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Form:
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Description:
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Molecular Formula:
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Content And Storage:
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Quantity:
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