MilliporeSigma™ Calbiochem™ Indomethacin, 2'-Trifluoromethyl

Description

• A cell-permeable, bioavailable 2′-trifluoromethyl analog of Indomethacin ( Cat
• No
• 405268) that acts as a highly potent, time-dependent inhibitor of cyclooxygenase -2 (COX-2; IC 50 = 267 and 388nM for mouse and human COX-2, respectively) and its several mutant forms
• Does not affect COX-1 activity even at high concentrations (IC 50 >100μM)
• Interacts with human COX-2 with much greater affinity than indomethacin (K I = 1.5 vs 13μM) and blocks COX-2 dependent arachidonic acid oxygenation (IC 50 = 150nM in 1483 human head and neck squamous cell carcinoma cells)
• Further, minimizes swelling in carrageenan-induced rat paw edema model (EC 50 = 1.7mg/kg, p.o.) with no gastrointestinal bleeding at higher doses (10mg/kg).