50-966-50001

MilliporeSigma™ Calbiochem™ Glucokinase Activator III, Ro-28-1675

Manufacturer: MilliporeSigma™

CAS Number: 300353-13-3

Select a Size

Pack Size SKU Availability Price
Each of 1 50-966-50001-Each-of-1 In Stock ₹ 26,049.60

50-966-50001 - Each of 1

₹ 26,049.60

In Stock

Quantity

1

Base Price: ₹ 26,049.60

GST (18%): ₹ 4,688.928

Total Price: ₹ 30,738.528

Color

White

Target Proteins

Glucokinase

Molecular Formula

C18H22N2O3S2

Content And Storage

Protect from light

Quantity

10 mg

Description

98% by HPLC

CAS

300353-13-3

Solubility

DMSO

Form

Powder

Other Options

Image Product Name Manufacturer Price Range
50-250-0971
eMolecules​ Medchem Express / RO-28-1675 / 5mg / 446258937 / HY-10595 / / 300353-13-3 / MFCD12546328 / 378.510 / C18H22N2O3S2
eMolecules​ ₹ 32,493.98
AF32617
300353-13-3 | Ro 28-1675
A2B Chem ₹ 15,058.56 - ₹ 67,677.96

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Description

  • A cell-permeable thiazolyl-propanamide compound that acts as a glucokinase (GK) activator by increasing V max and decreasing [S] 1/2 of GK-catalyzed reaction as well as freeing GK from the inhibitory action of GK regulatory protein (GKRP), resulting in increased
  • Induces GK nuclear-to-cytosol translocation in primary rat hepatocytes and reduces glucose concentration for insulin secretion stimulation from isolated rat pancreatic islets (threshold [glucose] = 3mm vs 6mm with or without 3μM Ro-28-1675)
  • Exhibits in vivo glucose-lowering and insulin-releasing activity in non-diabetic C57BL/6 mice and Wistar rats and is efficacious in several murine and rodent type II diabetes mellitus (T2DM) models (10 to 50mg/kg via p.o.)
  • Does not affect hexokinase I or II activity.

Compare Similar Items

Show Difference

Img

MilliporeSigma™

50-966-50001

--


Color:
White

Target Proteins:
Glucokinase

Molecular Formula:
C18H22N2O3S2

Content And Storage:
Protect from light

Quantity:
10 mg

Description:
98% by HPLC

CAS:
300353-13-3

Solubility:
DMSO

Form:
Powder

Img

MilliporeSigma™

50-966-70001

--


Color:
Light Yellow

Target Proteins:
VprBP

Molecular Formula:
C19H17N5S

Content And Storage:
Protect from light

Quantity:
10 mg

Description:
98% by HPLC

CAS:
__

Solubility:
DMSO

Form:
Powder

Img

Fischer Scientific

50-967-6

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Color:
__

Target Proteins:
__

Molecular Formula:
__

Content And Storage:
4° C, store in dark, DO NOT FREEZE!

Quantity:
25 Tests

Description:
__

CAS:
__

Solubility:
__

Form:
Liquid

Img

Fischer Scientific

50-967-7

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Color:
__

Target Proteins:
__

Molecular Formula:
__

Content And Storage:
4° C, store in dark, DO NOT FREEZE!

Quantity:
100 Tests

Description:
__

CAS:
__

Solubility:
__

Form:
Liquid