MilliporeSigma™ Calbiochem™ PICK1 PDZ Domain Inhibitor, FSC231

Description

• A cell-permeable acryloylcarbamate compound that selectively targets the PDZ (PSD-95/Discs-large/ZO-1 homology) domain of PICK1 (protein interacting with C kinase 1), but not those of PSD-95 (postsynaptic density protein 95) and GRIP1 (glutamate receptor interacting protein 1), effectively competing against dopamine transporter/DAT ( K i ∽10μM), GluR2 ( K i ∽10μM), and mRluR7a, c-terminus binding to PICK1 PDZ
• Shown to accelerate internalized GluR2 surface recycling and suppress both long-term depression and potentiation in rat and murine hippocampal neurons.