53-123-70001

MilliporeSigma™ Calbiochem™ IRAK4 Inhibitor, Compound 26

Manufacturer: MilliporeSigma™

Select a Size

Pack Size SKU Availability Price
Each of 1 53-123-70001-Each-of-1 In Stock ₹ 21,595.34

53-123-70001 - Each of 1

₹ 21,595.34

In Stock

Quantity

1

Base Price: ₹ 21,595.34

GST (18%): ₹ 3,887.161

Total Price: ₹ 25,482.501

Color

Pale Yellow

Target Proteins

IRAK4

Solubility

DMSO

Form

Powder

Description

98% by HPLC

Molecular Formula

C25H27N5O2

Content And Storage

Protect from light

Quantity

10 mg

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Description

  • A cell permeable indolo[2,3-c]quinoline derivatived compound that acts as a selective and highly potent inhibitor of interleukin-1 receptor associated kinase (IRAK4; IC 50 = 94 pM)
  • Displays much reduced potency against IRAK1 (IC 50 = 65nM) and displays high selectivity over a panel of other 27 kinases, including several involved in TLR-mediated signaling
  • Blocks R848-induced TNF-α and IL-6 production in primary human monocytes and inhibits LPS-induced TNF-α production in mice (100 mpk)
  • Shows minimal inhibition of Cyp2C9, 2D6, and 3A4 and has excellent microsomal stability and desirable aqueous solubility (100mg/mL at pH 7.4)
  • Please note that the molecular weight for this compound is batch-specific due to variable water content.

Compare Similar Items

Show Difference

Img

MilliporeSigma™

53-123-70001

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Color:
Pale Yellow

Target Proteins:
IRAK4

Solubility:
DMSO

Form:
Powder

Description:
98% by HPLC

Molecular Formula:
C25H27N5O2

Content And Storage:
Protect from light

Quantity:
10 mg

Img

Invitrogen

53-124-182

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Color:
__

Target Proteins:
__

Solubility:
__

Form:
Liquid

Description:
__

Molecular Formula:
__

Content And Storage:
4° C, store in dark, DO NOT FREEZE!

Quantity:
100 μg

Img

Fischer Scientific

53-125-0

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Color:
White

Target Proteins:
__

Solubility:
Soluble to 50 mM in water and to 50 mM in DMSO

Form:
__

Description:
__

Molecular Formula:
C35H43N7O2·3HCl

Content And Storage:
__

Quantity:
50 mg

Img

eBioscience

53-127-842

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Color:
__

Target Proteins:
__

Solubility:
__

Form:
Liquid

Description:
__

Molecular Formula:
__

Content And Storage:
4° C, store in dark, DO NOT FREEZE!

Quantity:
100 Tests