7060150
MilliporeSigma™ Calbiochem™ Roscovitine
A potent, reversible, and selective inhibitor of Cdks that exhibits about 10-fold greater efficacy towards p34-cdk1 and p33-cdk2 and 20-fold greater efficacy towards p33-cdk5 relative to Olomoucine.
Manufacturer: Fischer Scientific
CAS Number: 186692-46-6
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Color
White to Off-white
Target Proteins
p34cdk1/cyclin B
Molecular Formula
C19H26N6O
Solubility
DMSO
Description
95% by HPLC
CAS
186692-46-6
Formula Weight
354.5g/mol
Form
Solid
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | MilliporeSigma™ Calbiochem™ Roscovitine | Fischer Scientific | ₹ 25,044.60 | |
| | MilliporeSigma™ Calbiochem™ Roscovitine | Fischer Scientific | ₹ 6,953.57 | |
 | Medchemexpress LLC Seliciclib | 186692-46-6 | MFCD02266401 | 10mg | Medchemexpress LLC | ₹ 7,382.55 | |
 | Sigma Aldrich Fine Chemicals Biosciences Roscovitine >=98% (TLC) | 186692-46-6 | MFCD02266401 | 5MG | Sigma Aldrich Fine Chemicals Biosciences | ₹ 43,501.42 | |
| | Enzo Life Sciences (R)-Roscovitine (2mg). CAS: 186692-46-6 | Enzo Life Sciences | ₹ 9,723.25 | |
 | Sigma Aldrich Fine Chemicals Biosciences Roscovitine | 186692-46-6 | MFCD02266401 | 1 mg | Sigma Aldrich Fine Chemicals Biosciences | ₹ 12,428.85 | |
 | Apexbio Technology LLC potent CDK inhibitor 186692-46-6. MFCD02266401 | Apexbio Technology LLC | ₹ 17,800.00 | |
 | 186692-46-6 | Roscovitine | A2B Chem | ₹ 2,136.00 - ₹ 39,961.00 |
Related Products
Description
- Inhibits p34cdk1/cyclin B (IC50 = 650 nM), p33cdk2/cyclin A (IC50 = 700 nM), p33cdk2/cyclin E (IC50 = 700 nM), and p33cdk5/p35 (IC50 = 200 nM) by competing for the ATP binding domain of the kinases
- Exhibits reduced sensitivity towards related kinases including ERK1 and ERK2 (IC50 = 34μM and 14μM, respectively)
- Roscovitine does not significantly affect the activity of other protein kinases even at 100μM, including p34cdk4/cyclin D1 and p40cdk6/cyclin D2
- Compared to olomoucine, roscovitine displays increased anti-mitotic activity at the G1/S and G2/M phases of the cell cycle
- A 50mm (5mg/282μl) solution of Roscovitine (Cat
- No
- 557364) in DMSO is also available.
Compare Similar Items
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Color: White to Off-white
Target Proteins: p34cdk1/cyclin B
Molecular Formula: C19H26N6O
Solubility: DMSO
Description: 95% by HPLC
CAS: 186692-46-6
Formula Weight: 354.5g/mol
Form: Solid
Color:
White to Off-white
Target Proteins:
p34cdk1/cyclin B
Molecular Formula:
C19H26N6O
Solubility:
DMSO
Description:
95% by HPLC
CAS:
186692-46-6
Formula Weight:
354.5g/mol
Form:
Solid
Color: Reddish Brown
Target Proteins: Ca2+ uptake into mitochondria in vitro
Molecular Formula: C2H26Cl3N8O5Ru2
Solubility: deoxygenated H2O
Description: 97% by capillary electrophoresis
CAS: __
Formula Weight: 550.8g/mol
Form: Solid
Color:
Reddish Brown
Target Proteins:
Ca2+ uptake into mitochondria in vitro
Molecular Formula:
C2H26Cl3N8O5Ru2
Solubility:
deoxygenated H2O
Description:
97% by capillary electrophoresis
CAS:
__
Formula Weight:
550.8g/mol
Form:
Solid
Color: __
Target Proteins: P38MAPK
Molecular Formula: C21H16N3OSF
Solubility: DMSO
Description: 98% by HPLC
CAS: 152121-47-6
Formula Weight: 377.4g/mol
Form: Thin Film
Color:
__
Target Proteins:
P38MAPK
Molecular Formula:
C21H16N3OSF
Solubility:
DMSO
Description:
98% by HPLC
CAS:
152121-47-6
Formula Weight:
377.4g/mol
Form:
Thin Film
Color: Bright Yellow
Target Proteins: p38 MAP kinase
Molecular Formula: C21H16FN3OS·HCl
Solubility: DMSO or H2O
Description: 95% by HPLC
CAS: __
Formula Weight: 413.9g/mol
Form: Solid
Color:
Bright Yellow
Target Proteins:
p38 MAP kinase
Molecular Formula:
C21H16FN3OS·HCl
Solubility:
DMSO or H2O
Description:
95% by HPLC
CAS:
__
Formula Weight:
413.9g/mol
Form:
Solid