Anti-IL-23R Antibody, cytoplasmic

Description

• General description: Interleukin 23 receptor (IL-23R) is a type I cytokine receptor that is a subunit of the receptor for IL23A/IL23. IL-23R pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. IL-23R associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3.
• Specificity: This antibody recognizes the cytoplasmic domain of IL-23R. May detect other isoforms of IL-23R (see molecular weight).
• Immunogen: KLH-conjugated linear peptide corresponding to human IL-23R at and around the cytoplasmic domain.
• Application: Anti-IL-23R Antibody, cytoplasmic detects level of IL-23R & has been published & validated for use in WB, IH, ELISA, FC.
• Quality: Evaluated by Western Blot in Jurkat cell lysate.Western Blot Analysis: 1 µg/mL of this antibody detected IL-23R on 10 µg of Jurkat cell lysate.
• Target description: ~42 kDa Observed.May detect other isoforms of IL-23R produced by alternative splicing: isoform 1 (~72 kDa), isoform 2 (~43 kDa), isoform 3 (~41 kDa), isoform 4 (~20 kDa), isoform 5 (~30 kDa), isoform 6 (~43 kDa) and isoform 7 (~26 kDa).
• Other Notes: Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.