Anti-Actin, N-terminal antibody produced in rabbit

Description

• General description: Actin is a cytoskeletal protein that regulates cell motility, secretion, phagocytosis and cytokinesis. The NH2-terminal of actin may function as an antigen. This terminal may also modulate actin interactions and may associate with proteins such as myosin.
• Immunogen: synthetic actin N-terminal nonapeptide conjugated to KLH.
• Application: Anti-Actin, N-terminal antibody produced in rabbit has been used in immunoblottingquantitative chromatin immunoprecipitation (qChIP)
• Biochem/physiol Actions: Actin and myosin are constituents of many cell types and are involved in a myriad of cellular processes including maintenance of cell shape, locomotion, secretion, cytoplasmic streaming, phagocytosis, and cytokinesis. The N-terminal domain of actin appears to be a major antigenic region of the molecule. Different isoforms can coexist in the same cell but are differentially regulated, and in most cases cannot substitute for each other functionally.
• Physical form: Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% BSA and 15 mM sodium azide.
• Other Notes: To view an Actin antibody selection guide, please visit www.sigmaaldrich.com/actin.
• Disclaimer: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.