Anti-Calsequestrin-2 antibody produced in rabbit

Description

• General description: Calsequestrin is a major Ca2+ binding protein in cardiac and skeletal muscle.
• Immunogen: synthetic peptide corresponding to amino acids 57-74 of rat calsequestrin-2, conjugated to KLH. This sequence is highly conserved in human and rat calsequestrin-2 (single amino acid substitution). This sequence is not found in calsequestrin-1.
• Application: Anti-Calsequestrin-2 antibody has been used in immunoblotting, western blotting.
• Biochem/physiol Actions: Over expression of cardiac calsequestrin (CASQ2) is associated with depressed cardiovascular function and hypertrophy. Mutations in CASQ2 are thought to be associated with catecholaminergic polymorphic ventricular tachycardia (CPVT). It is a high-capacity, low-affinity Ca2+ binding glycoprotein, which functions as an internal Ca2+ store in the lumen of the sarcoplasmic reticulum (SR).
• Physical form: Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.
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