C7423

Monoclonal Anti-CD8 antibody produced in mouse

clone UCHT-4, purified immunoglobulin, buffered aqueous solution

Manufacturer: Sigma Aldrich

Synonym(S): Monoclonal Anti-CD8

Select a Size

Pack Size SKU Availability Price
100 TEST C7423-100-TEST In Stock ₹ 44,355.60

C7423 - 100 TEST

₹ 44,355.60

In Stock

Quantity

1

Base Price: ₹ 44,355.60

GST (18%): ₹ 7,984.008

Total Price: ₹ 52,339.608

biological source

mouse

Quality Level

200

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

UCHT-4, monoclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

flow cytometry: 5 μL using 1 × 106 cells

isotype

IgG2a

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Description

  • General description: Monoclonal Anti-Human CD8 (mouse IgG2a isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cell line NS-1 and splenocytes from BALB/c mice immunized with human thymocytes followed by peripheral blood T cells. CD8 (cluster of differentiation 8), is a dimeric protein, encoded by the CD8A gene mapped to human chromosome 2p12.
  • Specificity: Recognizes the CD8 human T cytotoxic/suppressor lymphocyte cell surface glycoprotein. Approximately 90% of thymocytes are stained in suspension. In thymus sections, both cortical and medullary thymocytes are stained. A subset of NK cells express this antigen weakly. The epitope recognized by this clone is sensitive to routine formalin fixation and paraffin embedding.3rd Workshop: code no. 567
  • Immunogen: human thymocytes followed by peripheral blood T cells.
  • Application: Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.Flow cytometry/Cell sorting (1 paper)Immunofluorescence (1 paper)
  • Biochem/physiol Actions: CD8 might serve as a marker for neoplastic diseases and acute myeloid leukemia.
  • Target description: CD8 is a two chain complex (α/α, α/β) receptor for Class I MHC molecules. The receptor′s cytoplasmic portion is associated with p56lck protein tyrosine kinase which phosphorylates nearby proteins. The antigen is strongly expressed on approximately one third of mature T cells (cytotoxic/suppressor T cells).
  • Physical form: Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide.
  • Disclaimer: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

SAFETY INFORMATION

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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