Anti-Calcitonin Gene Related Peptide antibody produced in rabbit

Description

• General description: Calcitonin Gene Related Peptide (CGRP), a cyclic peptide, belongs to a small family of peptides encoded by the calcitonin/CGRP gene complex. The calcitonin/CGRP gene complex consists of at least two genes, encoding for two forms of CGRP: -CGRP (CGRP-I) and -CGRP (CGRP-II). CGRP is synthesized and co-localized with calcitonin in the parafollicular C-cells of the thyroid gland and medullary thyroid carcinoma. It is principally considered a neuropeptide widely distributed in the central and peripheral nervous systems.
• Specificity: Anti-Calcitonin Gene Related Peptide reacts with CGRP (rat). Cross-reactivity is observed with CGRP (human) and β-CGRP (human).
• Immunogen: CGRP-KLH
• Application: Anti-Calcitonin Gene Related Peptide antibody produced in rabbit has been used in:dot blot immunoassayfluorescent labeling[1]confocal microscopy[1]immunohistofluorescence[2]epifluorescence imaging[2]
• Biochem/physiol Actions: CGRP is thought to act as a neurotransmitter or neuromodulator, particularly in the regulation of autonomic (e.g., cardiovascular, respiratory, gastrointestinal, taste, food intake and sleep) and limbic functions. CGRP is probably involved with substance P in mediating neurogenic inflammation and transmission of pain stimuli via the peripheral nervous system.
• Quantity: delipidized
• Physical form: Supplied as a liquid containing 0.1% sodium azide as a preservative
• Storage and Stability: For continuous use, store 2-8°C. For extended storage, solution may be frozen in working aliquots. Repeated freezing and thawing, or storage in "frost-free"freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify by centrifugation before use.
• Disclaimer: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.