Anti-β-Amyloid Protein (1-40) antibody produced in rabbit

Description

• General description: Amyloid precursor proteins (APPs) are members of a large family of 70 kDa transmembrane glycoproteins that are found in a wide range of tissues. APP is expressed in the brain. It is located on human chromosome 21. APPs have three main isoforms, namely, APP695, APP751 and APP770, that are derived from alternative splicing events in cells.
• Immunogen: synthetic β-amyloid (1-40) conjugated to BSA.
• Application: Anti-β-Amyloid Protein (1-40) antibody produced in rabbit has been used in:immunocytochemical localization of Aβ peptides immunocytochemistry immunoprecipitationfocused ultrasound-microbubble enhanced antibody delivery (FUS-MB)
• Biochem/physiol Actions: The β-amyloid precursor protein (APP) is cleaved sequentially by the proteolytic enzymes β-secretase (BACE1) and γ-secretase to produce β-amyloid (Aβ) peptides with the Aβ1-42 and the Aβ1-40 forms being the most prevalent. Secreted Aβ peptides are degraded either via a re-uptake mechanism followed by endosomal degradation, or by an extracellular insulin degrading enzyme. Extracellular accumulation of Aβ leads to the formation of aggregates, fibrils and eventually amyloid deposits called neuritic plaques, which is the hallmark of Alzheimer′s disease (AD).Rabbit Anti-β-Amyloid Protein (1-40) antibody does not stain control sections of normal brain tissues.
• Physical form: Rabbit Anti-β-Amyloid (1-40) is supplied as a liquid containing 0.1% sodium azide as preservative.
• Disclaimer: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.