Milli-Mark® Anti-Bcl-2 Antibody, Alexa Fluor™488, clone AW604

Description

• General description: Bcl-2 suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Bcl-2 also regulates cell death by controlling the mitochondrial membrane permeability and appears to function in a feedback loop system with caspases. It appears to Inhibit caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). Further understanding in how Bcl-2 functions and interacts with other proteins to promote or inhibit apoptosis may lead to new treatments for cancer, neurological disorders and autoimmune diseases.
• Specificity: Antibody recognizes Bcl-2.
• Immunogen: KLH-conjugated, synthetic peptide corresponding to human Bcl-2
• Application: Research CategoryApoptosis & Cancer
• Quality: Evaulated by flow cytometery using Jurkat cells.
• Target description: 26 kDa Calculated
• Physical form: Protein G Purified
• Storage and Stability: Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.
• Analysis Note: ControlJurkat Cells
• Legal Information: ALEXA FLUOR is a trademark of Life Technologies
• Disclaimer: Alexa Fluor™ is a registered trademark of Molecular Probes, Inc.