Milli-Mark® Anti-pan Histone-FITC Antibody, clone H11-4

Description

• General description: There are 5 main histone proteins involved in the structure of chromatin in eukaryotic cells. The five major classes of histones are H1/H5, H2A, H2B, H3, and H4. Histones H2A, H2B, H3 and H4 are known as the core histones, while histones H1 and H5 are known as the linker histones. Histones feature a main globular domain and a long N terminal tail which are involved with the structure of the nucleosomes of the ′beads on a string′ structure. They are the chief protein components of chromatin, acting as spools around which DNA winds, and play a role in gene regulation.
• Specificity: Due to the highly conserved nature of histones, this antibody is predicted to have wide species reactivity.
• Application: This Milli-Mark Anti-pan Histone-FITC Antibody, clone H11-4 is validated for use in FC for the detection of pan Histone.
• Quality: Evaluated by flow cytometry using HeLa cells.
• Target description: Antibody recognizes histones H1, H2A, H2B, H3, and H4. Calculated molecular weight for these histones range from 14 to 21 kDa
• Legal Information: MILLI-MARK is a registered trademark of Merck KGaA, Darmstadt, Germany