Anti-CLIC4 antibody produced in rabbit

Description

• Immunogen: Chloride intracellular channel protein 4 recombinant protein epitope signature tag (PrEST)
• Application: Anti-CLIC4 antibody produced in rabbit, a Prestige Antibody, is developed and validated by the Human Protein Atlas (HPA) project . Each antibody is tested by immunohistochemistry against hundreds of normal and disease tissues. These images can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. The antibodies are also tested using immunofluorescence and western blotting. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
• Biochem/physiol Actions: CLIC4 (chloride intracellular channel 4) gene encodes a chloride intracellular channel that belongs to the CLIC family of chloride channels. It binds to H3R (Histamine H3 receptor), a G protein-coupled receptor that negatively regulates neurotransmitter release, and promotes receptor cell surface expression. Its expression is up-regulated by TGF-β1 in myofibroblasts. TGF-β1 mediates the conversion of fibroblasts into myofibroblasts. Increased expression of CLIC4 is found to inhibit cell motility. It colocalizes with AKAP350, a scaffolding protein for several protein kinases and phosphatases, at the centrosome and midbody, and regulates cytoskeletal organization during the cell cycle. It may be involved in the formation of vessel lumen during tubular morphogenesis. It promotes endothelial cell proliferation and morphogenesis and may function in angiogenesis. It is capable of forming a redox-regulated ion channel.
• Features and Benefits: Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.Every Prestige Antibody is tested in the following ways:IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.Protein array of 364 human recombinant protein fragments.
• Linkage: Corresponding Antigen APREST71220
• Physical form: Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide
• Legal Information: Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany
• Disclaimer: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.