Anti-ZNF503 antibody produced in rabbit

Description

• General description: Zinc finger 703 (ZNF703), also referred to as zinc finger elbow-related proline domain protein 2 (zeppo2) and nocA-like zinc finger 1 (NoLZ1), belongs to the nocA-elbow (elB)-tlp (NET) protein family. ZNF703 is ubiquitously expressed in human tissue and it is predominantly expressed in lateral ganglionic eminence (LGE). The protein is encoded by the gene mapped to human chromosome 10.The encoded protein is characterized with typical C2H2 zinc-finger motif.
• Immunogen: zinc finger protein 503 recombinant protein epitope signature tag (PrEST)
• Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.
• Biochem/physiol Actions: Zinc finger 703/ nocA-like zinc finger 1 (NoLZ1) control development and function of striatal neurons by promoting retinoic acid signaling in lateral ganglionic eminence (LGE). The protein might function as a transcriptional repressor. NOLZ1 expression in vLGE (ventral LGE) can be regulated by Gro-TLE co- repressor. ZNF703 plays a crucial role in mammary gland homeostasis and alteration in the expression of this protein might increase the risk for breast cancer development.
• Features and Benefits: Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.Every Prestige Antibody is tested in the following ways:IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.Protein array of 364 human recombinant protein fragments.
• Linkage: Corresponding Antigen APREST86707
• Physical form: Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.
• Legal Information: Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany
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