HPA045910

Anti-CRBN antibody produced in rabbit

Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

Manufacturer: Sigma Aldrich

Synonym(S): Anti-MRT2, Anti-MRT2A

Select a Size

Pack Size SKU Availability Price
100 μL HPA045910-100-μL In Stock ₹ 48,995.40

HPA045910 - 100 μL

₹ 48,995.40

In Stock

Quantity

1

Base Price: ₹ 48,995.40

GST (18%): ₹ 8,819.172

Total Price: ₹ 57,814.572

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

product line

Prestige Antibodies® Powered by Atlas Antibodies

form

buffered aqueous glycerol solution

species reactivity

mouse, human, rat

enhanced validation

RNAi knockdownLearn more about Antibody Enhanced Validation

Related Products

Img

Sigma Aldrich

HPA001873

Prestige Antibodies® Powered by Atl...

Img

Sigma Aldrich

HPA002192

Ab2, Prestige Antibodies® Powered b...

Img

Sigma Aldrich

HPA005525

Prestige Antibodies® Powered by Atl...

Img

Sigma Aldrich

HPA004052

Prestige Antibodies® Powered by Atl...

Img

Sigma Aldrich

HPA000612

Prestige Antibodies® Powered by Atl...

Img

Sigma Aldrich

HPA006161

Prestige Antibodies® Powered by Atl...

Img

Sigma Aldrich

HPA004890

Prestige Antibodies® Powered by Atl...

Img

Sigma Aldrich

HPA042935

Prestige Antibodies® Powered by Atl...

Description

  • General description: The gene CRBN (cereblon) is mapped to human chromosome 3p26.2. It is strongly expressed in the brain. The encoded protein has a conserved Lon (ATP-dependent protease La) domain. The CRBN protein is present in the cytoplasm and nucleus.CRBN protein interacts with:DDB1 (anti-DDB1 HPA068456)SLC16A1 (anti-SLC16A1 HPA071055)BSG (anti-BSG HPA036048)PSMB4 (anti-PSMB4 HPA006700)PRKAA1 (anti-PRKAA1 HPA064946)
  • Immunogen: cereblon recombinant protein epitope signature tag (PrEST)
  • Application: All Prestige Antibodies®Powered by Atlas Antibodies is developed and validated by the Human Protein Atlas (HPA) project . Each antibody is tested by immunohistochemistry against hundreds of normal and disease tissues. These images can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.Anti-CRBN antibody produced in rabbit has been used in western blotting.
  • Biochem/physiol Actions: CRBN (cereblon) mainly recruits substrates for E3 ubiquitin ligase. It interacts with BKCa (calcium-activated potassium channel subunit α-1), ClC-2 (chloride channel protein 2), AMPK (5′-AMP-activated protein kinase), PSMB4 (proteasome subunit β 4), ikaros (IKZF1), aiolos (IKZF3) and MEIS2 (Meis1-related protein). These interactions might be required for sending the proteins for ubiquitination by the E3 ubiquitin ligase.[1] Degradation of IKZF1 (ikaros family zinc finger protein 1) and IKZF3 by lenalidomide (immunomodulatory drug)-bound CRBN helps in anti-myeloma effect of lenalidomide. Similarly, treatment with thalidomide in CRBN positive cells is effective in elderly patients with multiple myeloma. CRBN might also be associated with autosomal recessive nonsyndromic intellectual disability.[2]
  • Features and Benefits: Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.Every Prestige Antibody is tested in the following ways:IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.Protein array of 364 human recombinant protein fragments.
  • Linkage: Corresponding Antigen APREST79292
  • Physical form: Solution in phosphate buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.
  • Legal Information: Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany
  • Disclaimer: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

SAFETY INFORMATION

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Compare Similar Items

Show Difference

Img

Sigma Aldrich

HPA045910

Prestige Antibodies® Powered by Atl...


biological source:
rabbit

Quality Level:
100

conjugate:
unconjugated

antibody form:
affinity isolated antibody

antibody product type:
primary antibodies

clone:
polyclonal

product line:
Prestige Antibodies® Powered by Atlas Antibodies

form:
buffered aqueous glycerol solution

species reactivity:
mouse, human, rat

enhanced validation:
RNAi knockdownLearn more about Antibody Enhanced Validation

Img

Sigma Aldrich

HPA045919

Prestige Antibodies® Powered by Atl...


biological source:
rabbit

Quality Level:
100

conjugate:
unconjugated

antibody form:
affinity isolated antibody

antibody product type:
primary antibodies

clone:
polyclonal

product line:
Prestige Antibodies® Powered by Atlas Antibodies

form:
buffered aqueous glycerol solution

species reactivity:
human

enhanced validation:
recombinant expressionLearn more about Antibody Enhanced Validation

Img

Sigma Aldrich

HPA045930

Prestige Antibodies® Powered by Atl...


biological source:
rabbit

Quality Level:
100

conjugate:
unconjugated

antibody form:
affinity isolated antibody

antibody product type:
primary antibodies

clone:
polyclonal

product line:
Prestige Antibodies® Powered by Atlas Antibodies

form:
buffered aqueous glycerol solution

species reactivity:
human

enhanced validation:
recombinant expressionorthogonal RNAseqLearn more about Antibody Enhanced Validation

Img

Sigma Aldrich

HPA045934

Prestige Antibodies® Powered by Atl...


biological source:
rabbit

Quality Level:
100

conjugate:
unconjugated

antibody form:
affinity isolated antibody

antibody product type:
primary antibodies

clone:
polyclonal

product line:
Prestige Antibodies® Powered by Atlas Antibodies

form:
buffered aqueous glycerol solution

species reactivity:
human

enhanced validation:
orthogonal RNAseqLearn more about Antibody Enhanced Validation