Anti-Integrin αVβ5 Antibody, clone P1F6

Description

• General description: The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha V chain. Alpha chain V undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.
• Specificity: Reacts with the human integrin alphaVbeta5.
• Immunogen: Human UCLA P3 cells (lung carcinoma)
• Application: Inhibition of attachment of HT29 cells to vitronectin: >1:1,000 Inhibition of attachment of carcinoma and melanoma cells to vitronectin. Immunohistochemistry: for use on acetone or paraformaldehyde fixed tissue. (Staining of formalin-fixed tissues REQUIRES boiling tissue sections in 1mM EDTA, pH 8.0, for 10-20 min followed by cooling at RT for 20 min.) Immunocytochemistry: 1:1500. For use on human carcinomas, normal epithelium and keratinocytes (Acetone Fixed Only). Immunoprecipitation FACS EIA Optimal working dilutions must be determined by the end user.
• Physical form: Format: Purified
• Storage and Stability: Maintain for 1 year at 2–8°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Analysis Note: ControlEpithelium, keratinocytes
• Other Notes: Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
• Legal Information: CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
• Disclaimer: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.