MABC1145

Anti-FAP Antibody, clone 73.3

clone 73.3, from mouse

Manufacturer: Sigma Aldrich

Synonym(S): Fibroblast activation protein, Propyl endopeptidase FAP, Dipeptidyl peptidase FAP, Serine integral membrane protease, SIMP

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Pack Size SKU Availability Price
100 μG MABC1145-100-μG In Stock ₹ 45,730.00

MABC1145 - 100 μG

₹ 45,730.00

In Stock

Quantity

1

Base Price: ₹ 45,730.00

GST (18%): ₹ 8,231.40

Total Price: ₹ 53,961.40

biological source

mouse

Quality Level

100

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

73.3, monoclonal

species reactivity

mouse

technique(s)

flow cytometry: suitable

isotype

IgG1κ

NCBI accession no.

NP_032012

UniProt accession no.

P97321

Description

  • General description: Fibroblast activation protein (UniProt: ; also known as Propyl endopeptidase FAP, Dipeptidyl peptidase FAP, Serine integral membrane protease, SIMP) is encoded by the Fap gene (Gene ID: 14089) in murine species. FAP is a homodimeric type II transmembrane protein that physically attaches to cells and bulk of the protein is exposed to extracellular space. It is a gelatinase of the serine protease family that is selectively expressed by tumor associated fibroblasts and pericytes in a majority of human epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. It is not expressed in most normal tissues, but is expressed during embryonic development. It is present as a homodimer and homodimerization is required for activity of both plasma membrane and soluble forms. It can also form heterodimer with DPP4. Both plasma membrane and soluble forms exhibit post-proline cleaving endopeptidase activity, with a marked preference for Ala/Ser-Gly-Pro-Ser/Asn/Ala consensus sequences. Its gelatinase activity is inhibited by several serine-protease inhibitors, such as PMSF, AEBSF, and diisopropyl fluorophosphate (DFP). FAP is involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis. It is also involved in the cell invasiveness towards the ECM in malignant melanoma cancers. (Ref.: Kelly, T et al. (2012). Int. Rev. Cell Mol. Biol. 297:83-116; Santos, AM et al. (2009). J. Clin. Invest. 119(12):3613-3625).
  • Specificity: Clone 73.3 specifically detects fibroblast activation protein (FAP) in 3T3 cells overexpressing FAP.
  • Immunogen: FAP-expressing 3T3 cells.
  • Application: Detect fibroblast activation protein using this mouse monoclonal Anti-FAP Antibody, clone 73.3, Cat. No. MABC1145. It has been tested in Flow Cytometry.
  • Quality: Isotype testing: Identity Confirmation by Isotyping Test. Isotyping Analysis: The identity of this monoclonal antibody is confirmed by isotyping test to be mouse IgG1 .
  • Target description: 87.94 kDa calculated.
  • Physical form: Format: Purified
  • Storage and Stability: Stable for 1 year at 2-8°C from date of receipt.
  • Other Notes: Concentration: Please refer to lot specific datasheet.
  • Disclaimer: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

SAFETY INFORMATION

WGK

WGK 1

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biological source:
mouse

Quality Level:
100

antibody form:
purified immunoglobulin

antibody product type:
primary antibodies

clone:
73.3, monoclonal

species reactivity:
mouse

technique(s):
flow cytometry: suitable

isotype:
IgG1κ

NCBI accession no.:
NP_032012

UniProt accession no.:
P97321

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