Anti-Delta3 Antibody, clone 1E7.2

Description

• General description: DLL3, also known as Delta like ligand 3, is a transmembrane Delta-like protein principally found in the Golgi apparatus and endosomes where it promotes Notch family receptor degradation to inhibit primary neurogenesis. DLL3 is one of five DSL proteins that bind to the Notch receptor. Notch signaling pathways play key roles in cell-fate determination and differentiation in many tissues during embryonic and postnatal development. Notch ligands family members are characterized by a DSL domain, EGF repeats, and a transmembrane domain. Mutations in the DLL3 gene causes autosomal recessive spondylocostal dysostosis.
• Immunogen: Linear peptide corresponding to human Delta3.
• Application: Flow Cytometry Analysis: 0.1 µg from a representative lot detected Delta3 in HEK293 cells.
• Quality: Evaluated by Western Blot in human liver tissue lysate.Western Blot Analysis: 0.5 µg/mL of this antibody detected Delta3 on 10 µg of human liver tissue lysate.
• Target description: ~65 kDa observed
• Physical form: Format: Purified
• Storage and Stability: Stable for 1 year at 2-8°C from date of receipt.
• Analysis Note: ControlHuman liver tissue lysate
• Other Notes: Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
• Disclaimer: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.