Anti-PMP70 antibody produced in rabbit

Description

• General description: The 70 kDa peroxisomal membrane protein (PMP70) is a major component of peroxisomal membranes. The peroxisome is a multifunctional single-membrane organelle associated with eukaryotic cells. PMP70 belongs to the ATP binding cassette (ABC) transporter superfamily.
• Immunogen: synthetic peptide corresponding to amino acid residues 644-659 of rat PMP70 with N-terminal added cysteine, conjugated to KLH. The corresponding sequence is identical in mouse and differs by one amino acid in human.
• Application: Anti-PMP70 antibody produced in rabbit has been used in:immunocytochemistryimmunostainingimmunofluorescencewestern blottingimmunoprecipitation
• Biochem/physiol Actions: PMP70 participates in the metabolic transport of long and very long fatty acids into peroxisomes. PMP70 interacts and forms a stable complex with the adrenoleukodystrophy protein(ALDP), and also with several other peroxisomal proteins. ATP binding/hydrolysis by PMP70 and ALDL and their phosphorylation are involved in the regulation of fatty acid transport into peroxisomes. Mutations in the PMP70 (PXMP1) gene may cause a subset of Zellweger syndrome, an autosomal recessive disorder and is characterized by defects in import mechanism for peroxisomal matrix enzymes.
• Physical form: Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
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