SAB1306492

ANTI-ZO1(C-TERMINAL) antibody produced in rabbit

purified immunoglobulin, buffered aqueous solution

Manufacturer: Sigma Aldrich

Synonym(S): TJP1, Tight junction protein 1, Tight junction protein ZO-1, ZO1, Zona occludens protein 1

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Pack Size SKU Availability Price
400 μL SAB1306492-400-μL In Stock ₹ 56,521.20

SAB1306492 - 400 μL

₹ 56,521.20

In Stock

Quantity

1

Base Price: ₹ 56,521.20

GST (18%): ₹ 10,173.816

Total Price: ₹ 66,695.016

biological source

rabbit

Quality Level

100

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

195459 Da

species reactivity

human

technique(s)

flow cytometry: 1:10-1:50immunohistochemistry: 1:50-1:100western blot: 1:1000

NCBI accession no.

NP_003248.3

Description

  • General description: Tight junction protein 1 (TJP1) or zona occludens protein 1 (ZO1) is an adaptor protein. It acts as a scaffold protein between the tight junction and actin cytoskeleton. ZO1 has a molecular weight of 220kDa and is part of the membrane-associated guanylate kinase homolog family. The protein possesses three PDZ domains at its amino terminal, an SH3 domain and a region which bears homology to guanylate kinase. The ZO1 gene is localized on human chromosome 15q13.1.
  • Application: ANTI-ZO1(C-TERMINAL) antibody produced in rabbit has been used in immunofluorescence.
  • Biochem/physiol Actions: Tight junction protein 1 (TJP1) or zona occludens protein 1 (ZO1) has a role in the formation of epithelial lumens. It interacts with occludin and modulates tight junction barrier regulation. ZO1 is also involved in the formation of the odontoblast layer and in actomyosin cytoskeleton regulation. Low expression of ZO1 has been linked to increased cell invasiveness in breast cancer, colorectal cancer and digestive tract cancers.
  • Physical form: Supplied in PBS with 0.09% (W/V) sodium azide
  • Disclaimer: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

SAFETY INFORMATION

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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