Anti-GPR39 (C-terminal region) antibody produced in rabbit

Description

• General description: GPR39 (G protein-coupled receptor 39) is an orphan member of the ghrelin receptor family expressed in brain and other peripheral tissues.
• Application: Anti-GPR39 (C-terminal region) antibody produced in rabbit has been used in immunohistochemistry.
• Biochem/physiol Actions: G-protein coupled receptor 39 (GPR39) has been shown to be important regulators of food intake, energy metabolism and glucose homeostasis. GPR39 signals mainly through the Gαq and Gα12/13 leading to inositol phosphate accumulation and activation of downstream pathways such as the nuclear factor of activated T cells (NFAT) transcriptional pathway. GPR39 has been suggested to mediate glutamate metabotropic signaling triggered by synaptically released Zn2+ in the hippocampus. Knockout of GPR39 in mice is found to be associated with impaired insulin secretion, glucose tolerance and altered pancreatic β-cell gene expression and function, suggesting that this receptor could be a novel potential target for the treatment of diabetes.
• Physical form: Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.
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