Anti-PSPC1 antibody, Mouse monoclonal

Description

• General description: Monoclonal Anti-PSPC1 (mouse IgG1 isotype) is derived from the hybridoma 1L4 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide corresponding to a sequence at the C-terminal region of mouse PSPC1. DBHS (Drosophila behavior, human splicing) protein family, consisting also of NONO (nonPOU-domain-containing, octamer binding protein) and SFPQ (splicing factor, praline- and glutamine-rich). NONO, paraspeckle component 1 (PSPC1) and SFPQ are the core protein components of paraspeckles. These multi-functional nuclear proteins, under normal conditions, cycle between the nucleoplasm, paraspeckles and the nucleolus.
• Immunogen: Synthetic peptide corresponding to a sequence at the C-terminal region of mouse PSPC1, conjugated to KLH. 1 The corresponding sequence is identical in rat and human PSPC1.
• Application: Monoclonal Anti-PSPC1 antibody produced in mouse has been used in immunohistochemistry, immunoblotting and immunofluorescence.
• Biochem/physiol Actions: Drosophila behavior, human splicing (DBHS) proteins bind both double- and single-stranded DNA and RNA, and are involved in various aspects of RNA and DNA metabolism, such as transcription, pre-mRNA 3′ processing, transcription termination and mRNA splicing. DBHS proteins regulate circadian rhythm and carcinogenesis. PSPC1 activates androgen receptor mediated transcription. PSPC1 forms a heterodimer with NONO that localizes to paraspeckles in a RNA polymerase II-dependent manner.
• Physical form: Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
• Disclaimer: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.