Monoclonal Anti-CD44-FITC antibody produced in mouse

Description

• General description: The CD44 (cell-surface glycoprotein) gene with 20 exons is mapped to human chromosome 11p13. The gene codes for a transmembrane glycoprotein.
• Immunogen: Leukocytes of a patient suffering from LGL Type Leukaemia.
• Application: Monoclonal Anti-CD44-FITC antibody produced in mouse has been used as a reagent to distinguish HeLa (cancer) cells from chondrocyte (normal) cells.
• Biochem/physiol Actions: CD44 (cell-surface glycoprotein) is involved in cell-cell and cell-extracellular matrix interactions. It plays an important role in lymphocyte homing and lymphocyte activation. It also acts as a metastasis suppressor gene for prostatic cancer. Overexpression of CD44 leads to esophageal squamous cell carcinoma (ESCC). CD44 inhibits macrophage multinucleation by interacting with its ligands, hyaluronic acid, chondroitin sulfates and osteopontin. 100kDa form of CD44, facilitates the binding of poliovirus to HeLa cells. In addition, it also implicated in the infection of mononuclear phagocytes by human immunodeficiency virus (HIV).
• Features and Benefits: Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
• Physical form: Solution in phosphate buffered saline containing 15 mM sodium azide and 0.2% high-grade protease free BSA as a stabilizing agent.
• Disclaimer: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.