Monoclonal Anti-CD71-PE antibody produced in mouse

Description

• General description: Cluster of differentiation 71 (CD71), also known as transferrin receptor, is encoded by the gene mapped to human chromosome 3q29. CD71 is present on cells with high proliferation.
• Immunogen: NALM-6 human pre-B cell line
• Application: Monoclonal Anti-CD71-PE antibody produced in mouse has been used to estimate the cell surface transferrin receptor (TfR) levels.
• Biochem/physiol Actions: Cluster of differentiation 71 (CD71) functions as an iron regulatory protein. Overexpression of the gene has been associated with the development of various types of cancers, including cholangiocarcinoma (CCA). Thus, CD71 protein is considered as a potential therapeutic target for CCA and iron overload. The encoded protein facilitates mitochondrial respiration and reactive oxygen species (ROS) production in human pancreatic ductal adenocarcinoma (PDAC) cells, which is essential for their tumorigenic growth. Thus, aberrant expression of CD71 might also lead to the development of pancreatic cancer.
• Features and Benefits: Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
• Physical form: Solution in phosphate buffered saline containing 15 mM sodium azide and 0.2% high-grade protease free BSA as a stabilizing agent.
• Disclaimer: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.