Anti-PTEN antibody, Rabbit monoclonal

Description

• General description: Phosphatase and tensin homolog deleted on chromosome ten (PTEN), a lipid phosphatase protein, is localized in the cell nucleus. It has a protein tyrosine phosphatase domain. The PTEN gene is located on human chromosome 10q23.
• Immunogen: Synthetic peptide derived from the C-terminus of human PTEN protein.
• Biochem/physiol Actions: Phosphatase and tensin homolog deleted on chromosome ten (PTEN) is a tumor suppressor gene. It negatively regulates the phosphatidylinositol 3-kinase (PI3K) pathway. PTEN protein might control the growth of cells through its lipid phosphatase activity. The protein tyrosine phosphatase domain of PTEN is known to dephosphorylate serine, threonine, and tyrosine residues. It may also participate in immune modulation. Mutation in the PTEN gene is associated with rare bilateral choroidal ganglioneuroma. Germline mutations in the PTEN gene are observed in Cowden′s syndrome (CS), Lhermitte–Duclos disease (LDD), and Bannayan–Zonana syndrome (BZS).
• Features and Benefits: Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
• Physical form: 0.1 ml rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.
• Disclaimer: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.