Phospho-EGFR (pSer1070) ELISA Kit

Description

• General description: The Human BLC ELISA (Enzyme-Linked Immunosorbent Assay) kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human BLC in serum, plasma, cell culture supernatants and urine.The EGFR (epidermal growth factor receptor) family includes four receptor tyrosine kinases, EGF R (ErbB1), ErbB2 (neu), ErbB3, and ErbB4.[1][2] EGF R is present on many cell types of epithelial and mesenchymal lineages. The gene EGFR is mapped to human chromosome 7p11.2.[3]
• Immunogen: EGFR (pTyr1070) synthetic phosphopeptide
• Application: For research use only. Not for use in diagnostic procedures.Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)
• Biochem/physiol Actions: The members of epidermal growth factor receptor (EGF R) or the ErbB receptor family have been identified as useful biomarkers and targets for cancer therapy.[2] EGF R binds EGF and induces tyrosine phosphorylation leading to proliferation of cells.[1] EGF R is capable of binding transforming growth factor-α and heparin-binding EGF in addition to EGF.[4] There are numerous effector molecules activated by EGF R that result in a variety of biological processes such as morphogenesis, cell motility, apoptosis, differentiation and organ repair and maintenance. Deregulation of EGF R signaling is implicated in progression of a wide variety of tumors, invasion and metastasis.[1][4] Phosphorylation of Tyr1068 occurs by autophosphorylation of EGF R and is required for the binding of Grb2 (Growth factor receptor-bound protein 2) and activation of ERK1/2 (extracellular signal-regulated kinases) pathway.[5]