Dipeptidyl Peptidase VII human

Description

• Application: Dipeptidyl Peptidase VII (DPP7), also known as DPP2 or quiescent cell proline dipeptidase, is a post-proline cleaving aminopeptidase that is expressed in quiescent lymphocytes [1]. DPP7 is used to study the regulation of cell quiescence [2]. Like DPP4, DPP7 may be useful in diabetes and vascular disease research [3].
• Biochem/physiol Actions: DPP7 is essential for maintaining lymphocytes and fibroblasts in G(0). The inhibition of DPP7 results in apoptosis, which is mediated by the induction of c-Myc and p53 [2]. DPP7 has strong sequence homology with prolylcarboxypeptidase and is active at both acidic and neutral pH.
• Physical properties: Contains amino acids 29 to end with a C-terminal His tag, MW=89.1 kDa
• Unit Definition: One unit will hydrolyze 1.0 picomole of Ala-Pro-AMC per minute at pH 7.4 at 25 deg °C
• Physical form: Supplied as a solution in 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 220 mM imidazole, and 20% glycerol.