Dapagliflozin propanediol
United States Pharmacopeia (USP) Reference Standard
Manufacturer: Sigma Aldrich
CAS Number: 960404-48-2
Synonym(S): Dapagliflozin propanediol monohydrate, (1S)-1,5-Anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-D-glucitol (S)-propane-1,2-diol (1:1) monohydrate, (2S,3R,4R,5S,6R)-2-(3-(4-Ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyl-tetrahydro-2H-pyran-3,4,5-triol propanediol monohydrate, BMS 512148 propanediol hydrate, BMS-512148 propanediol hydrate, Dapagliflozin (S)-propylene glycol monohydrate, Dapagliflozin propanediol hydrate
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 100 MG | 1163253-100-MG | In Stock | ₹ 1,01,289.53 |
1163253 - 100 MG
In Stock
Quantity
1
Base Price: ₹ 1,01,289.53
GST (18%): ₹ 18,232.115
Total Price: ₹ 1,19,521.645
packaging
pkg of 100 mg
manufacturer/tradename
USP
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
InChI
1S/C21H25ClO6.C3H8O2.H2O/c1-2-27-15-6-3-12(4-7-15)9-14-10-13(5-8-16(14)22)21-20(26)19(25)18(24)17(11-23)28-21;1-3(5)2-4;/h3-8,10,17-21,23-26H,2,9,11H2,1H3;3-5H,2H2,1H3;1H2/t17-,18-,19+,20-,21+;3-;/m10./s1
InChI key
GOADIQFWSVMMRJ-UPGAGZFNSA-N
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Description
- General description: This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
- Application: Dapagliflozin propanediol USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia.
- Biochem/physiol Actions: Dapagliflozin (BMS-512148) is an orally active, potent and selective renal sodium-dependent glucose cotransporter 2 (SGLT2; SLC5A2) inhibitor (human/rat SGLT2 IC50 = 1.1/3 nM vs. human/rat SGLT1 IC50 = 1.39/0.6 μM; R-methyl-D-glucopyranoside (AMG) uptake assay with respective CHO transfectants). Dapagliflozin reduces blood glucose levels (by 55% in streptozotocin (STZ)-induced hyperglycemic rats 5 hrs post 0.1 mg/kg p.o.) by preventing the renal glucose reabsorption process and promoting glucose excretion in urine with good pharmacokinetic properties and oral availability (84% in rats and 83% in dogs, respectively, post 1 mg/kg and 6.6 mg/kg p.o.) in vivo.
- Analysis Note: These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.
- Other Notes: Sales restrictions may apply.
SAFETY INFORMATION
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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packaging: pkg of 100 mg
manufacturer/tradename: USP
application(s): pharmaceutical (small molecule)
format: neat
storage temp.: 2-8°C
InChI: 1S/C21H25ClO6.C3H8O2.H2O/c1-2-27-15-6-3-12(4-7-15)9-14-10-13(5-8-16(14)22)21-20(26)19(25)18(24)17(11-23)28-21;1-3(5)2-4;/h3-8,10,17-21,23-26H,2,9,11H2,1H3;3-5H,2H2,1H3;1H2/t17-,18-,19+,20-,21+;3-;/m10./s1
InChI key: GOADIQFWSVMMRJ-UPGAGZFNSA-N
packaging: __
manufacturer/tradename: __
application(s): __
format: __
storage temp.: __
InChI: 1S/C6H6ClN/c1-5-2-3-8-6(7)4-5/h2-4H,1H3
InChI key: MZVSTDHRRYQFGI-UHFFFAOYSA-N
packaging: pkg of 50 U
manufacturer/tradename: Roche
application(s): __
format: __
storage temp.: __
InChI: __
InChI key: __
