Description

• General description: Cotinine is an alkaloid found in tobacco as well as a major urinary metabolite of nicotine. This stable-labeled internal standard is suitable for quantitation of cotinine levels in urine, blood, and saliva for GC/MS or LC-MS/MS applications in nicotine testing or clinical and diagnostic testing of nicotine biomarkers.
• Application: Advanced mass spectrometry applications: A review covers high-performance liquid chromatography-mass spectrometry (HPLC-MS) methods, including the use of (±)-Cotinine-d₃ for the analysis of nicotine and its metabolite cotinine across various biological matrices, highlighting its role in accurate biomarker quantification (Jin et al., 2022).Exposure assessment in passive smoking: The study employs stable isotope dilution gas chromatography-triple quadrupole mass spectrometry with (±)-Cotinine-d₃ to determine urinary cotinine levels in children exposed to passive smoking, demonstrating its efficacy in environmental health research (Wang et al., 2014).Nicotine metabolism in special populations: Research utilizes a liquid chromatography-tandem mass spectrometry method to investigate nicotine metabolism in HIV-1-positive smokers, using (±)-Cotinine-d₃ to track metabolic variations, thereby aiding in personalized medicine approaches (Earla et al., 2014).Automated LC-MS-MS for cotinine detection: The development of an automated solid-phase extraction method for LC-MS-MS highlights the use of (±)-Cotinine-d₃ for streamlined and precise cotinine detection, applicable in clinical toxicology and therapeutic monitoring (Dunlop et al., 2014).Quantitative analysis in smoking cessation: A sensitive UPLC-tandem mass spectrometry procedure quantifies nicotine, cotinine, and their metabolites in plasma using (±)-Cotinine-d₃ as an internal standard, crucial for clinical studies on smoking cessation (Dobrinas et al., 2011).
• Legal Information: CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany