hnRNP K Monoclonal Antibody (F45 P9 C7), Invitrogen™

Description

• MA1-087 detects the hnRNP-K in human, rat, chicken, rabbit, and mouse cells
• By Western blot, this antibody detects a ∽51 kDa protein
• The MA1-087 immunogen is a synthetic peptide, conjugated to Ovalbumin, corresponding to residues S(453) V K Q Y S G K F F(463) of the hnRNP-K protein
• This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs)
• The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA)
• These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport
• While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm
• The hnRNP proteins have distinct nucleic acid binding properties
• The protein encoded by this gene is located in the nucleoplasm and has three repeats of KH domains that binds to RNAs
• It is distinct among other hnRNP proteins in its binding preference; it binds tenaciously to poly(C)
• This protein is also thought to have a role during cell cycle progression
• Several alternatively spliced transcript variants have been described for this gene, however, not all of them are fully characterized.