Hepatitis B Virus Surface Monoclonal Antibody (S 26), Invitrogen™

Description

• MA1-7603 detects HBsAg from virus samples
• MA1-7603 has been successfully used in ELISA procedures
• The MA1-7603 immunogen is HBsAg purified from human sera pool
• Store at 4oC short term; store at -80oC long term, avoiding freeze-thaw cycles
• The hepatitis B virus is an important cause of acute and chronic liver disease
• It is also the most common form of parenterally transmitted viral hepatitis
• The HBV surface protein antigens (HBsAg) are comprised of three carboxyl co terminal HBs proteins termed large (LHBs), middle (MHBs) and small (SHBs, also called major) protein
• LHBs and MHBs also share the highly hydrophobic, repetitive, membrane spanning S domain
• In addition, MHBs has a 55 amino acid region called preS2
• The virus is estimated to affect some 350 million people worldwide
• Immunization against hepatitis B is an important component of preventative medicine and is offered to all children in approximately 30 countries
• Hepatitis B virus (HBV) belongs to the Hepadnaviridae family and infection with HBV is usually more serious than infection with hepatitis A virus
• In some individuals the infection is not cleared and followed by persistent intracellular viral carriage that can lead to the development of hepatocelular carcinomas
• There are currently 400 million HBV carriers worldwide making HBV one of the most common human pathogens.