Hepatitis B Virus Core Antigen Monoclonal Antibody (10C6), Invitrogen™

Description

• This antibody can be used for ELISA, Western blot, IHC, and Immunoprecipitation of in vitro-translated core and pre-core proteins
• Strongly recognizes WHc (but not DHBc) in ELISA and immunoblot
• Reacts with synthetic HBc peptides
• Epitope: aa 138-145
• The hepatitis B virus is an important cause of acute and chronic liver disease
• It is also the most common form of parenterally transmitted viral hepatitis
• Hepatitis B virus is spherical in shape with a diameter of 42nm
• It contains a 27 nm partially double stranded DNA core enclosed within a lipoprotein coat
• The antigenic activity of the nucleocapsid core is designated as hepatitis B core antigen
• The antigens in the outer surface are called as hepatitis B virus surface antigens
• Core antigens are localized within the nuclei whereas the surface antigens are present in the cytoplasm of the infected cells
• Antibodies to surface antigens appear in circulation at an early stage of infection whereas the antibodies to the core antigens are detected after several weeks
• The virus is estimated to affect some 350 million people worldwide
• Immunization against hepatitis B is an important component of preventative medicine and is offered to all children in approximately 30 countries
• Hepatitis B virus (HBV) belongs to the Hepadnaviridae family and infection with HBV is usually more serious than infection with hepatitis A virus
• In some individuals the infection is not cleared and followed by persistent intracellular viral carriage that can lead to the development of hepatocelular carcinomas
• There are currently 400 million HBV carriers worldwide making HBV one of the most common human pathogens.