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07209I

MilliporeSigma™ phospho-SHC (Tyr239, Tyr240), Rabbit, Unlabeled, Polyclonal,

Manufacturer: MilliporeSigma™

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Pack Size	SKU	Availability	Price
Each of 1	07209I-Each-of-1	In Stock	₹ 40,197.80

07209I - Each of 1

₹ 40,197.80

In Stock

Quantity

Base Price: ₹ 40,197.80

GST (18%): ₹ 7,235.604

Total Price: ₹ 47,433.404

Antigen

phospho-SHC (Tyr239, Tyr240)

Classification

Polyclonal

Conjugate

Unconjugated

Gene

SHC1, SHC, SHCA

Host Species

Rabbit

Purification Method

Affinity Purified

Regulatory Status

RUO

Primary or Secondary

Primary

Test Specificity

Numbering of the target pTyr residues varies depending on the species and spliced isoforms. Target pTyr residues this rabbit polyclonal detects correspond to pTyr349/pTyr350 of human spliced isoform 6 and p66Shc, pTyr239/pTyr240 of human spliced isoform 7 and p52Shc, pTyr194/pTyr195 of isoform p46Shc, and pTyr135/pTyr136 of isoform 5 reported by UniProt (P29353).

Content And Storage

Stable for 1 year at 2°-8°C from date of receipt.

Applications

Western Blot

Concentration

Please refer to lot specific datasheet.

Formulation

Purified rabbit polyclonal antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.

Gene Accession No.

P29353

Immunogen

KLH-conjugated linear peptide corresponding to a target site sequence surrounding phosphorylated Tyr239 and Tyr240 of human spliced isoform p52Shc.

Quantity

100 μg

Research Discipline

Apoptosis & Cancer

Gene ID (Entrez)

NP_892113

Target Species

Human

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Description

SHC-transforming protein 1 (UniProt P29353; also known as SH2 domain protein C1, SHC-transforming protein 3, SHC-transforming protein A, Src homology 2 domain-containing-transforming protein C1) is encoded by the SHC1 (also known as SHC, SHCA) gene (Gene ID 6464) in human
Originally identified as an SH2-containing proto-oncogene involved in growth factor signaling, Shc proteins function as adaptor molecules recruited by numerous receptors (e.g
integrins, GPCRs, and receptors for growth factors, antigens, cytokines, and hormones) for signling
In addition to the ubiquitously expressed Shc (a.k.a
ShcA by SHC1/SHCA gene), there exist also ShcB (by SHC2/SHCB gene) and ShcC (by SHC3/SHCC gene), which are predominantly expressed in neuronal cells
Alternative splicings result in six ShcA isoforms, including p66Shc, p52Shc, and p46Shc
All ShcA isoforms possess two distinct domains, PTB (a.a
156-339) and SH2 (a.a
488-579), that bind phosphotyrosine-containing sequences, as well as a central region (CH1; a.a
340-487) that contains critical tyrosine phosphorylation sites
The phosphotyrosine-binding (PTB) domain is also referred to as phosphotyrosine-interaction domain or PID.

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MilliporeSigma™

07209I

Antigen:

phospho-SHC (Tyr239, Tyr240)

Classification:

Polyclonal

Conjugate:

Unconjugated

Gene:

SHC1, SHC, SHCA

Host Species:

Rabbit

Purification Method:

Affinity Purified

Regulatory Status:

RUO

Primary or Secondary:

Primary

Test Specificity:

Numbering of the target pTyr residues varies depending on the species and spliced isoforms. Target pTyr residues this rabbit polyclonal detects correspond to pTyr349/pTyr350 of human spliced isoform 6 and p66Shc, pTyr239/pTyr240 of human spliced isoform 7 and p52Shc, pTyr194/pTyr195 of isoform p46Shc, and pTyr135/pTyr136 of isoform 5 reported by UniProt (P29353).

Content And Storage:

Stable for 1 year at 2°-8°C from date of receipt.

Applications:

Western Blot

Concentration:

Please refer to lot specific datasheet.

Formulation:

Purified rabbit polyclonal antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.

Gene Accession No.:

P29353

Immunogen:

KLH-conjugated linear peptide corresponding to a target site sequence surrounding phosphorylated Tyr239 and Tyr240 of human spliced isoform p52Shc.

Quantity:

100 μg

Research Discipline:

Apoptosis & Cancer

Gene ID (Entrez):

NP_892113

Target Species:

Human

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Primary or Secondary:

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Gene Accession No.:

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Research Discipline:

Gene ID (Entrez):

Target Species:

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MilliporeSigma™ phospho-SHC (Tyr239, Tyr240), Rabbit, Unlabeled, Polyclonal,

Select a Size

Select a Size

Properties

Antigen

Classification

Conjugate

Gene

Host Species

Purification Method

Regulatory Status

Primary or Secondary

Test Specificity

Content And Storage

Applications

Concentration

Formulation

Gene Accession No.

Immunogen

Quantity

Research Discipline

Gene ID (Entrez)

Target Species

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