CD112 (Nectin-2) Monoclonal Antibody (R2.477), PE, eBioscience™, Invitrogen™

Description

• This R2.477 MAb reacts with human CD112 (also known as Nectin-2 or Poliovirus Receptor Related 2), a 60-65 kDa immunoglobulin-like transmembrane cell adhesion molecule
• This cell surface molecule is expressed on hematopoietic cells, endothelial, epithelial, as well as tumor cell lines such as Jurkat, U937, and MCF7
• CD112 is a ligand for DNAM-1 (CD226), a leukocyte adhesion molecule expressed on natural killer (NK) cells
• Interaction between CD112 and DNAM-1 promotes NK cytotoxic activity, leading to tumor cell lysis
• In addition to its role in tumor suppression, CD112 plays a cooperative role in cell-cell adhesion, particularly in the formation of adherens junctions between neighboring epithelial cells and fibroblasts
• CD112 can form homophilic and heterophilic interactions to regulate contact inhibition of cell movement and proliferation
• Finally, CD112 has been reported to be a receptor for herpesvirus entry into cells
• This MAb has been reported to block cell adhesion and herpesvirus entry
• This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain
• This protein is one of the plasma membrane components of adherens junctions
• It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses
• Variations in this gene have been associated with differences in the severity of multiple sclerosis
• Alternate transcriptional splice variants, encoding different isoforms, have been characterized.